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Indications and Dosage
Topical/Cutaneous
Inflammatory skin fungal infections Adult: Each g of cream contains isoconazole nitrate 10 mg and diflucortolone valerate 1 mg. Apply to the affected area bid. Once inflammation has subsided, treatment should be continued with isoconazole cream (without the steroid component).
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Contraindications
Tuberculous and syphilitic infections in the area to be treated, viral infections (herpes simplex, vaccinia, varicella and smallpox). Pregnancy.
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Special Precautions
Not to be used on skin creases due to presence of potent corticosteroid. Prolonged use may lead to skin thinning, loss of elasticity, dilatation of superficial blood vessels, telangiectasiae and ecchymoses especially when used on face or with occlusive dressings. Excessive use on damaged skin may lead to substantial systemic absorption resulting in depression of the hypothalmus-pituitary adrenal axis especially in children. Caution when used near the eye. Not recommended for use in infants and children.
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Adverse Reactions
Local reactions such as burning and itching.
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Action
Description:
Mechanism of Action: Isoconazole nitrate is an imidazole antifungal that is used in the treatment of superficial skin fungal infections. It is effective against dermatophytes and yeasts, yeast-like fungi and moulds. Diflucortolone valerate is a corticosteroid that suppresses inflammation in inflammatory and allergic skin conditions; it also relieves itching, burning and pain. They are used together for the treatment of inflammatory or eczematous skin fungal infections. |
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Storage
Store below 25°C.
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MIMS Class
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